Should alpha-blockers ever be used as antihypertensive drugs? Rev Urol. Alpha blockers are also called alpha-adrenergic blocking agents, alpha-adrenergic antagonists, adrenergic blocking agents and alpha-blocking agents. They are classified according to the receptor sensitivity. Alfuzosin. Available for Android and iOS devices. Should alpha-blockers ever be used as antihypertensive drugs? Alpha blockers can increase or decrease the effects of other medications you take. They are: 1. Selective Alpha Blockers Quinazolines. September 4, 2014. Alpha blockers lower blood pressure by keeping the hormone norepinephrine from tightening the muscles in the walls of smaller arteries and veins. Weber MA, Schiffrin EL, White WB, et al. Data sources include IBM Watson Micromedex (updated 2 Nov 2020), Cerner Multum™ (updated 2 Nov 2020), ASHP (updated 23 Oct 2020) and others. Some alpha blockers might have a "first-dose effect." alpha blockers are drugs that can treat bph, also called enlarged prostate. Alpha blockers are also called alpha-adrenergic blocking agents, alpha-adrenergic antagonists, adrenergic blocking agents and alpha-blocking agents. JAMA. As a result, the vessels remain open and relaxed. They are not typically prescribed as the first choice of medicine for hypertension, but are usually a third or fourth selection and are often used alongside other medications. However, some research has found that long-term use of some alpha blockers can increase the risk of heart failure. Some commonly prescribed alpha-blockers include: Other alpha blockers are available, both within the U.S. and around the world. 2019:477-482. doi:10.1016/B978-0-323-47871-7.00078-2. Prazosin. types of alpha blockers include: * alfuzosin (uroxatral) * doxazosin (cardura) * prazosin (minipress) * silodosin (rapaf phenoxybenzamine, phentolamine J Hypertens. Alpha blockers, also called alpha-adrenergic blocking agents, work by interfering with the transfer of messages to specific parts of the body. Read our, Medically reviewed by Yasmine S. Ali, MD, MSCI, Medically reviewed by Richard N. Fogoros, MD, Medically reviewed by Jurairat J. Molina, MD, Medically reviewed by Ana Maria Kausel, MD, Medically reviewed by Jamin Brahmbhatt, MD, Why Hypertension Is a Leading Cause of Heart Disease, Your Complete Guide to Hypertension Drugs, Inspra (Eplerenone) Side Effects and Risks, What You Should Know About Cardene (Nicardipine), An Ace Inhibitor Used for Hypertension and Heart Failure, How to Treat Diastolic Dysfunction and Heart Failure, Metoprolol: Used to Treat High Blood Pressure and Angina. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Instead, they're used in combination with other drugs, such as diuretics, when your high blood pressure is difficult to control. Last updated on Sep 19, 2019. Alpha blockers are also called alpha-adrenergic blocking agents, alpha-adrenergic antagonists, adrenergic blocking agents and alpha-blocking agents. Short-acting medications work quickly, but their effects last only a few hours. 2010;77(12):884,887-888. 2002;288(23):2981-97. doi:10.1001/jama.288.23.2981. Alpha blockers work by keeping the hormones of norepinephrine or noradrenaline at bay, leading to smoother blood flow through open veins. Women are generally not prescribed alpha-blockers because they can cause urinary stress incontinence and loss of bladder control. In addition, women who are pregnant, breastfeeding or may become pregnant should not take alpha-blockers. Alpha-1 adrenergic receptors are present in vascular smooth muscle, the central nervous system, and other tissues. This is probably due to the effects they have on lowering blood pressure. 2013;31:1281. doi:10.1097/01.hjh.0000431740.32696.cc. When you start taking an alpha blocker, you might develop pronounced low blood pressure and dizziness, which can make you faint when you rise from a sitting or lying position. All rights reserved. Be sure to notify your doctor if you fall into any of the above categories, and to supply the names of any other medicines and/or supplements you are taking. Like other \"blocker\" medications, alpha blockers attach themselves to molecules in the body that serve as receptors for certain chemical messages. In addition to high blood pressure, doctors prescribe alpha blockers to prevent, treat or improve symptoms of an enlarged prostate (benign prostatic hyperplasia). Before taking an alpha blocker, be sure your doctor knows about other medications you take, such as beta blockers, calcium channel blockers or medications for erectile dysfunction. Side effects of alpha-blocker use: Retrograde ejaculation. Kaplan SA. We comply with the HONcode standard for trustworthy health information -. Alpha-blockers are also associated with an increased risk of falling and of breaking a bone (fracture) when they are first started. Alpha-blockers are medicines that are mainly used to treat high blood pressure (hypertension) and problems with passing urine in men who have enlargement of the prostate gland. Are your medications causing or increasing incontinence? Because alpha blockers also relax other muscles throughout the body, these medications also can help improve urine flow in older men with prostate problems. Why Peeing May Feel Weird When You're Taking Cold Medicine. Alpha blockers work by keeping the hormone norepinephrine (noradrenaline) from tightening the muscles in the walls of smaller arteries and veins, which causes the vessels to remain open and relaxed. Cleveland Clinic Journal of Medicine. classification of alpha blockers, general effects of blockers ,and its pharmacological actions, drugs with therapeutic uses and its side effects Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. Ⓒ 2020 About, Inc. (Dotdash) — All rights reserved, Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. 2013 ESH/ESC guidelines for the management of arterial hypertension: The task force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). Byrd JB, Venkata C, Ram S, Lerma EV. types of alpha blockers include: * alfuzosin (uroxatral) * doxazosin (cardura) * prazosin (minipress) * silodosin (rapaf Alpha blockers work by keeping the hormone norepinephrine (noradrenaline) from tightening the muscles in the walls of smaller arteries and veins. Benzensulfonamides. Mancia G, Fagard R, Narkiewicz K, et al. © 1998-2019 Mayo Foundation for Medical Education and Research (MFMER). Alpha blockers are also used to treat other illnesses, including: While other medicines are usually tried before considering alpha-blockers, for some patients they represent an important treatment option.. Cardiovascular side effects. The alpha blocker that's best for you depends on your health and the condition being treated.